Welcome!
Spatial & Genome Technologies Core (SGT Core)
University of Illinois Chicago – Research Resources Center
The Spatial & Genome Technologies (SGT) Core is part of the UIC Research Resources Center (RRC), supporting researchers in the design, execution, and analysis of single cell and spatial projects.
Director: Melissa Leone – mleone@uic.edu
Manager: Yujun Feng – yujunf2@uic.edu
We collaborate closely with other UIC cores, including the UIC Biorepository, Histology Research Core, Research Informatics Core, and the University of Illinois DNA Services Lab, to support seamless, end-to-end research workflows.
The SGT Core empowers the UIC research community by providing access to 10x Genomics solutions and expert guidance in:
Spatial transcriptomics
Single cell genomics
We support projects from experimental design through data interpretation, ensuring scientifically rigorous and reproducible results.
We offer standardized workflows and technical support for spatial assays using 10x Genomics platforms:
Visium HD Gene Expression
Visium Spatial Gene Expression
Xenium In Situ Gene Expression
We also advise on tissue preparation and quality control to ensure optimal assay performance.
We provide validated workflows and expert support for single cell profiling using the 10x Genomics Chromium system:
3' Gene Expression (standard whole transcriptomic RNAseq)
5' Gene Expression (enables TCR and BCR assembly)
Flex Gene Expression (probe-based transcriptome profiling for human and mouse samples)
Epi ATAC (open chromatin profiling)
Epi Multiome (ATAC + Gene Expression from the same cell)
Add-on Protein Expression (cell surface and intracellular protein detection)
We’re here to help you match the right technology to your scientific question. Contact us to discuss your goals and identify the most suitable platform for your project.
Reach out to request a consultation — we’re ready to help you design, execute, and interpret high-impact single cell and spatial studies.
| Hours | Location |
|
Monday - Friday |
Room E616, MSB |
| Name | Role | Phone | Location | |
|---|---|---|---|---|
| Melissa Leone |
Director
|
7739010294
|
mleone@uic.edu
|
Room E621 MSB
|
| Yujun Feng |
Manager
|
2176074611
|
yujunf2@uic.edu
|
Room E616 MSB
|
| Service Prices |
| ► Consultation (1) | |||
| Name | Description | Price | |
|---|---|---|---|
| Consultation |
meet to discuss project and their goals ~30 min |
Internal
$0.00
each
External (Academic US ONLY) $0.00 each External (Corporate and Foreign) $0.00 each External CBC $0.00 each External Collaboration (A) $0.00 each |
|
| ► Optimization (1) | |||
| Name | Description | Price | |
| Test Count - Cell viability assessment by AOPI staining (Fx7 automated cell counter) |
Assessment of sample quality prior to scheduling the exp Price per sample |
Internal
$30.00
Sample
External (Academic US ONLY) $47.97 Sample External (Corporate and Foreign) $47.97 Sample |
|
| ► scRNAseq (13) | |||
| Name | Description | Price | |
| 10x Genomics 3’ Single Cell Gene Expression - 1 Sample |
microfluidic cell processing + cDNA amplification and QC + library preparation Price per sample |
Internal
$2,503.00
Sample
External (Academic US ONLY) $4,002.00 Sample External (Corporate and Foreign) $4,002.00 Sample |
|
| 10x Genomics 3’ Single Cell Gene Expression - 2 Samples |
microfluidic cell processing + cDNA amplification and QC + library preparation |
Internal
$4,570.00
each
External (Academic US ONLY) $7,308.00 each External (Corporate and Foreign) $7,308.00 each |
|
| 10x Genomics 3’ Single Cell Gene Expression - 3 Samples |
microfluidic cell processing + cDNA amplification and QC + library preparation |
Internal
$6,637.00
each
External (Academic US ONLY) $10,613.00 each |
|
| 10x Genomics 3’ Single Cell Gene Expression - 4 Samples |
microfluidic cell processing + cDNA amplification and QC + library preparation |
Internal
$8,704.00
each
External (Academic US ONLY) $13,918.00 each External (Corporate and Foreign) $13,918.00 each |
|
| 10x Genomics 3’ Single Cell Gene Expression - 4 Samples (HT kit) |
microfluidic cell processing + cDNA amplification and QC + library preparation |
Inquire | |
| 10x Genomics 3’ Single Cell Gene Expression - 6 Samples (HT kit) |
microfluidic cell processing + cDNA amplification and QC + library preparation |
Inquire | |
| 10x Genomics 3’ Single Cell Gene Expression - 8 Samples (HT kit) |
microfluidic cell processing + cDNA amplification and QC + library preparation |
Inquire | |
| 10x Genomics Single Cell ATAC v2 - 3 samples |
nuclei isolation + microfluidic cell processing + library preparation |
Inquire | |
| 10x Genomics Single Cell ATAC v2 - 6 samples |
nuclei isolation + microfluidic cell processing + library preparation |
Inquire | |
| 10x Genomics Single Cell ATAC v2 - 7 samples |
nuclei isolation + microfluidic cell processing + library preparation |
Inquire | |
| 10x Genomics Single Cell Fixed RNA profile- 4 Samples (Singleplex) |
QC + hybridization + microfluidic cell processing + library preparation + websummary |
Inquire | |
| 10x Genomics 3’ Single Cell Gene Expression + Cell Surface Protein Labeling- 2 Samples |
CITE-Seq: Cell Staining + microfluidic cell processing + cDNA amplification and QC + library preparation (gene expression and Cell Surface Protein) |
Inquire | |
| 10x Genomics 3’ Single Cell Gene Expression + Cell Surface Protein Labeling- 3 Samples |
CITE-Seq: Cell Staining + microfluidic cell processing + cDNA amplification and QC + library preparation (gene expression and Cell Surface Protein) |
Inquire | |
| ► Sequencing (6) | |||
| Name | Description | Price | |
| Library QC for 1 pooled library |
clean-up, Qubit, tapestation and qPCR on pooled library |
Internal
$85.00
each
External (Academic US ONLY) $136.00 each External (Corporate and Foreign) $136.00 each |
|
| Library QC for 2-8 samples |
QC on individual libraries, pooling + clean-up, Qubit, tapestation and qPCR on pooled library |
Internal
$221.62
each
External (Academic US ONLY) $354.37 each External (Corporate and Foreign) $354.37 each |
|
| Library QC for 2-8 samples (qPCR on individual libraries) |
library QC+ qPCR quantification, pooling + clean-up, Qubit, tapestation and qPCR on pooled library |
Inquire | |
| Nova X Plus 10B , Paired-reads, 28x90 |
1.2B clusters per lane |
Internal
$1,690.00
each
External (Academic US ONLY) $2,702.00 each External (Corporate and Foreign) $2,702.00 each External CBC $1,690.00 each External Collaboration (A) $1,859.00 each |
|
| Nova X Plus 10B, Paired-reads, 2x150 |
1.2B clusters per lane
|
Internal
$2,190.00
each
External (Academic US ONLY) $3,502.00 each External (Corporate and Foreign) $3,502.00 each External CBC $2,190.00 each External Collaboration (A) $2,409.00 each |
|
| Nova X Plus 25B, 2x150 |
3B clusters per lane |
Internal
$3,240.00
each
External (Academic US ONLY) $5,261.00 each External (Corporate and Foreign) $5,261.00 each External CBC $3,240.00 each External Collaboration (A) $3,619.00 each |
|
| ► Data Analysis (2) | |||
| Name | Description | Price | |
| Genome alignment and generation of count matrix |
Alignment, filtering & counting Price per sample |
Internal
$50.00
Sample
External (Academic US ONLY) $80.00 Sample External (Corporate and Foreign) $80.00 Sample |
|
| Genome alignment and generation of count matrix - CITEseq |
Alignment, filtering & counting (gene expression + cell surface protein expression) Price per sample |
Inquire | |
| ► Advance Bioinformatics Analysis (8) | |||
| Name | Description | Price | |
| Data management and storage | Inquire | ||
| Data management, storage and back up |
price for 6 months |
Inquire | |
| Project execution |
Price per project |
Internal
$618.00
each
External (Academic US ONLY) $988.00 each External (Corporate and Foreign) $988.00 each External CBC $618.00 each External Collaboration (A) $679.80 each |
|
| Data QC |
price per sample |
Inquire | |
| Speudo-time/trajectories (Monocle/Slingshot) |
less than 40,000 cells |
Inquire | |
| Cell-Cell communication NicheNet |
price for project execution |
Inquire | |
| Cell-cell communication (CellChat) |
price for project execution |
Inquire | |
| Additional bioinformatics support |
Price per hour |
Internal
$85.00
/hr
External (Academic US ONLY) $135.92 /hr External (Corporate and Foreign) $135.92 /hr |
|
